Very difficult , I had to use a trick for the 31 major palaces , evolving them from a single tent after protecting the whole eastern bank by a maze . This trick keep the patrician population very low , avoiding any 2d and 3rd foods problem ( as you know , feeding whith imported food is the best C3 nightmare ... ).
City is not stable , as to reach 100 culture I needed to pick most of the workers to staff schools , universities etc ...
Defence just fit the job , 3 legionaries , 3 javelins and >50 towers in " comb walls " , some invasions were hard to deal whith !
I had to refresh the census once , very boring whith this setting , as I had to devolve first the patricians ,open maze, devolve the plebs , evove the plebs , close the maze and evolve patricians in time for the end of the year !